ABOUT DEEPEN-iRBD
We are a consortium of 8 academics and CEO of patients association from Italy, Luxembourg, Sweden, France, Denmark and Croatia whose research project DEEPEN-iRBD aims at defining a model for early risk stratification, diagnosis, treatment, and prognosis of patients with idiopathic REM sleep behavior disorder (iRBD). Our personalized medicine research initiative aims at developing a multi-level stratification strategy to predict into which alpha-synucleinopathy (Parkinson’s Disease, Multiple system Atrophy and Dementia with Lewy Bodies) an IRBD patient will convert to, and to enable future interventional, neuroprotective studies for secondary and tertiary prevention for iRBD patients at the earliest possible phase. Indeed, evidence shows that individuals affected by iRBD have a high risk of conversion to PD, multiple system atrophy and dementia with Lewy bodies conditions that have a common cellular pathological hallmark, the aggregation of alpha-synuclein. This project is fully funded by ERA PerMed.
OUR GOAL
The DEEPEN-iRBD project
The main objective of the DEEPEN-iRBD project is to detect distinct profiles beyond iRBD that enable the early diagnosis and differentiation of the three synucleopathies, even during the prodromal stage before any cognitive or motor symptoms become apparent. The study will make use of both existing and newly obtained data, such as recordings of physiological signals, molecular markers extracted from body fluids, skin biopsy samples, and brain cells derived from reprogrammed skin cells of patients.
ABOUT ERA PERMED
ERA PerMed is a new ERA-Net Cofund
Supported by the European Commission, ERA PerMed is a new ERA-Net Cofund involving 32 partners from 23 countries. Its primary focus is to align national research strategies, promote excellence, enhance the competitiveness of European players in Personalised Medicine, and foster collaboration between Europe and non-EU countries. As part of this initiative, national funding organizations have agreed to launch Joint Transnational Calls, inviting innovative research projects in Personalised Medicine that encourage collaboration among multiple stakeholders.
DEEPEN-iRBD 